Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation.

@article{Neve2016SubcellularRP,
  title={Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation.},
  author={Jonathan Neve and Kaspar Burger and Wencheng Li and Mainul Hoque and Radhika Patel and Bin Tian and Monika Gullerova and Andr{\'e} Martin Furger},
  journal={Genome research},
  year={2016},
  volume={26 1},
  pages={24-35}
}
Alternative cleavage and polyadenylation (APA) plays a crucial role in the regulation of gene expression across eukaryotes. Although APA is extensively studied, its regulation within cellular compartments and its physiological impact remains largely enigmatic. Here, we used a rigorous subcellular fractionation approach to compare APA profiles of cytoplasmic and nuclear RNA fractions from human cell lines. This approach allowed us to extract APA isoforms that are subjected to differential… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 14 times over the past 90 days. VIEW TWEETS