Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy

Abstract

BACKGROUND Mutations in Matrin 3 [MATR3], an RNA- and DNA-binding protein normally localized to the nucleus, have been linked to amyotrophic lateral sclerosis (ALS) and distal myopathies. In the present study, we have used transient transfection of cultured cell lines to examine the impact of different disease-causing mutations on the localization of Matrin… (More)
DOI: 10.1371/journal.pone.0142144

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