Subcellular Localization of Hexokinases I and II Directs the Metabolic Fate of Glucose

@inproceedings{John2011SubcellularLO,
  title={Subcellular Localization of Hexokinases I and II Directs the Metabolic Fate of Glucose},
  author={Scott A. John and James N. Weiss and Bernard Ribalet},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND The first step in glucose metabolism is conversion of glucose to glucose 6-phosphate (G-6-P) by hexokinases (HKs), a family with 4 isoforms. The two most common isoforms, HKI and HKII, have overlapping tissue expression, but different subcellular distributions, with HKI associated mainly with mitochondria and HKII associated with both mitochondrial and cytoplasmic compartments. Here we tested the hypothesis that these different subcellular distributions are associated with different… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Development and regulation of glucose transporter and hexokinase expression in rat.

The American journal of physiology • 1994
View 5 Excerpts
Highly Influenced

Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function.

The Journal of experimental biology • 2003
View 6 Excerpts
Highly Influenced

The Relationships between Substrates and Enzymes of Glycolysis in Brain.

The Journal of biological chemistry • 1964
View 5 Excerpts
Highly Influenced

The kinetics and regulation of rat brain hexokinase.

The Journal of biological chemistry • 1971
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…