Subcellular Localization of Axl1, the Cell Type-Specific Regulator of Polarity

@article{Lord2002SubcellularLO,
  title={Subcellular Localization of Axl1, the Cell Type-Specific Regulator of Polarity},
  author={Matthew E Lord and Fumika Inose and Takatoshi Hiroko and Toshihiro Hata and Atsushi Fujita and John F. Chant},
  journal={Current Biology},
  year={2002},
  volume={12},
  pages={1347-1352}
}
Bud-site selection in yeast offers an attractive system for studying cell polarity and asymmetric division. Haploids divide in an axial pattern, whereas diploids divide in a bipolar pattern. AXL1 is expressed in haploids but not diploids, and ectopic expression of AXL1 in diploids converts their bipolar budding pattern to an axial pattern. How Axl1 acts as a switch between the bipolar and axial patterns is not understood. Here we report that Axl1 localizes to the mother-bud neck and division… CONTINUE READING

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