Subcellular Localization of Axl1, the Cell Type-Specific Regulator of Polarity

  title={Subcellular Localization of Axl1, the Cell Type-Specific Regulator of Polarity},
  author={Matthew E Lord and Fumika Inose and Takatoshi Hiroko and Toshihiro Hata and Atsushi Fujita and John F. Chant},
  journal={Current Biology},
Bud-site selection in yeast offers an attractive system for studying cell polarity and asymmetric division. Haploids divide in an axial pattern, whereas diploids divide in a bipolar pattern. AXL1 is expressed in haploids but not diploids, and ectopic expression of AXL1 in diploids converts their bipolar budding pattern to an axial pattern. How Axl1 acts as a switch between the bipolar and axial patterns is not understood. Here we report that Axl1 localizes to the mother-bud neck and division… CONTINUE READING


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Publications referenced by this paper.
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Patterns of bud-site selection GTP exchange factor involved in linking a spatial landmark

  • J. Chant, J. R. Pringle
  • 1995
Highly Influential
10 Excerpts

A role for a protease in morpho - uniform localization at the plasma membrane results in genic responses during yeast cell fusion

  • L. Marsh
  • J . Cell Biol .
  • 1998

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