Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology.

@article{Adams2016SubcellularCI,
  title={Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology.},
  author={Stephanie L. Adams and Kathy Tilton and James A. Kozubek and Sudha Seshadri and Ivana Delalle},
  journal={Journal of neuropathology and experimental neurology},
  year={2016},
  volume={75 8},
  pages={
          779-790
        }
}
Genome-wide association studies have established BIN1 (Bridging Integrator 1) as the most significant late-onset Alzheimer disease (AD) susceptibility locus after APOE We analyzed BIN1 protein expression using automated immunohistochemistry on the hippocampal CA1 region in 19 patients with either no, mild, or moderate-to-marked AD pathology, who had been assessed by Clinical Dementia Rating and CERAD scores. We also examined the amygdala, prefrontal, temporal, and occipital regions in a subset… CONTINUE READING