Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries.

@article{HansenSchwartz2003SubarachnoidHE,
  title={Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries.},
  author={Jacob A Hansen-Schwartz and Natalie L\ovland Hoel and Mingfang Zhou and Cang-Bao Xu and Niels Aage Svendgaard and Lars Edvinsson},
  journal={Neurosurgery},
  year={2003},
  volume={52 5},
  pages={1188-94; 1194-5}
}
OBJECTIVE Inspired by organ culture-induced changes in the vascular endothelin (ET) receptor population, we investigated whether such changes occur in cerebral arteries in a rat subarachnoid hemorrhage (SAH) model. METHODS SAH was induced with injection of 250 microl of blood into the prechiasmatic cistern. After 2 days, the middle cerebral artery, basilar artery, and posterior communicating artery were harvested. Pharmacological studies were performed in vitro, and levels of messenger… CONTINUE READING

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