Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.

@article{Krystal1994SubanestheticEO,
  title={Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.},
  author={John H. Krystal and Laurence P. Karper and John Seibyl and G K Freeman and Richard C. Delaney and James Douglas Bremner and George R. Heninger and Malcolm B. Bowers and Dennis S. Charney},
  journal={Archives of general psychiatry},
  year={1994},
  volume={51 3},
  pages={
          199-214
        }
}
BACKGROUND To characterize further behavioral, cognitive, neuroendocrine, and physiological effects of subanesthetic doses of ketamine hydrochloride in healthy human subjects. Ketamine, a phencyclidine hydrochloride derivative, is a dissociative anesthetic and a noncompetitive antagonist of the N-methyl-D-aspartate subtype of excitatory amino acid receptor. METHODS Nineteen healthy subjects recruited by advertisements from the community participated in this randomized, double-blind, placebo… 
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Effects of the noncompetitive N-methyl-D-aspartate receptor antagonist ketamine on visual signal detection performance in rats
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