Subanesthetic Doses of Ketamine Transiently Decrease Serotonin Transporter Activity: A PET Study in Conscious Monkeys

@article{Yamamoto2013SubanestheticDO,
  title={Subanesthetic Doses of Ketamine Transiently Decrease Serotonin Transporter Activity: A PET Study in Conscious Monkeys},
  author={Shigeyuki Yamamoto and Hiroyuki Ohba and Shingo Nishiyama and Norihiro Harada and Takeharu Kakiuchi and Hideo Tsukada and Edward F. Domino},
  journal={Neuropsychopharmacology},
  year={2013},
  volume={38},
  pages={2666-2674}
}
Subanesthetic doses of ketamine, an N-methyl-D-aspartic acid (NMDA) antagonist, have a rapid antidepressant effect which lasts for up to 2 weeks. However, the neurobiological mechanism regarding this effect remains unclear. In the present study, the effects of subanesthetic doses of ketamine on serotonergic systems in conscious monkey brain were investigated. Five young monkeys underwent four positron emission tomography measurements with [11C]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl… CONTINUE READING
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A high resolution animal PET scanner using compact PS-PMT detectors

  • M Watanabe, H Okada, K Shimizu, T Omura, E Yoshikawa, T Kosugi
  • IEEE Trans Nucl Sci 44: 1277–1282.
  • 1997
Highly Influential
1 Excerpt

Quantification of dopamine transporter in human brain using PET with 18 FFEPE 2 I

  • T Sasaki, H Ito, Y Kimura, R Arakawa, H Takano, C Seki
  • J Nucl Med
  • 2012
1 Excerpt

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