Subacute toxicity of all-trans- and 13-cis-isomers of N-ethyl retinamide, N-2-hydroxyethyl retinamide, and N-4-hydroxyphenyl retinamide.

@article{Sani1983SubacuteTO,
  title={Subacute toxicity of all-trans- and 13-cis-isomers of N-ethyl retinamide, N-2-hydroxyethyl retinamide, and N-4-hydroxyphenyl retinamide.},
  author={Brahma P Sani and Robert Meeks},
  journal={Toxicology and applied pharmacology},
  year={1983},
  volume={70 2},
  pages={228-35}
}
The major limitation for continuous administration of natural retinoids for chemoprevention of cancer is their high toxicity; however, synthetic retinamides have the desirable quality of reduced toxicity while retaining most of the biological activity. We have presently evaluated the comparative toxicity of all-trans- and 13-cis-isomers of N-ethyl retinamide (ER), N-2-hydroxyethyl retinamide (HER), and N-4-hydroxyphenyl retinamide (HPR) in mice and rats after po and ip administration. The… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

BMS-189453, a novel retinoid receptor antagonist, is a potent testicular toxin.

Toxicological sciences : an official journal of the Society of Toxicology • 2001
View 4 Excerpts
Highly Influenced

Effect of all-trans-retinoic acid on the development of chronic hypoxia-induced pulmonary hypertension.

Circulation journal : official journal of the Japanese Circulation Society • 2010

Nonenzymatic isomerization of 9-cis-retinoic acid catalyzed by sulfhydryl compounds.

Drug metabolism and disposition: the biological fate of chemicals • 1997
View 1 Excerpt

Similar Papers

Loading similar papers…