Subacute sensory ataxia and optic neuropathy with thiamine deficiency

  title={Subacute sensory ataxia and optic neuropathy with thiamine deficiency},
  author={Marco Spinazzi and Corrado Angelini and Cesare Patrini},
  journal={Nature Reviews Neurology},
Background. A 71 year-old man with a history of partial gastrectomy presented to the emergency department with subacute gait instability associated with painful dysesthesias and clumsiness in both hands. 10 years before presentation he had received a diagnosis of megaloblastic anemia, with no neurological involvement, as a result of vitamin B12 and folate deficiency, for which he was receiving regular supplements.Investigations. Neurological examination; routine laboratory testing; MRI of the… 
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Optic Neuropathies Caused by Micronutrients Deficiencies
  • M. Spinazzi
  • Medicine
    Handbook of Nutrition, Diet, and the Eye
  • 2019
Neuro-ophthalmic Manifestations of Wernicke Encephalopathy
This review highlights the neuro-ophthalmic manifestations of THE AUTHORS to guide the clinician in identifying the condition and provides an update regarding the clinical characteristics, pathophysiology, neuroimaging and laboratory findings, treatment options, and prognosis of THEY.
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It is concluded that pure‐ form of alcoholic neuropathy (ALN) was distinct from pure‐form of thiamine‐deficiency neuropathy(TDN), supporting the view that alcoholic neuroopathy can be caused by direct toxic effect of ethanol or its metabolites.
The syndrome of acute sensory neuropathy
The acute, often focal onset suggests an immune-mediated or vascular process at the level of the posterior root or dorsal root ganglion.
The pattern and diagnostic criteria of sensory neuronopathy: a case–control study
In the study population, sensory neuronopathy showed a common clinical and electrophysiological pattern that was independent of the underlying cause, including unusual forms with only patchy sensory loss, mild electrical motor nerve abnormalities and predominant small fibre or isolated lower limb involvement.
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The pattern of symmetric, non-length dependent neuropathic pain with face and trunk involvement suggests a selective disorder of the dorsal ganglia cells subserving small nerve fibres, which can be distinguished from distal SFN.
Sensory conduction study in chronic sensory ataxic neuropathy.
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Three months after gastric partitioning for morbid obesity, two patients developed an unusual and severe form of polyneuropathy that affected their sense of position maximally. This disorder produced