Subacute oral toxicity study of bisphenol F based on the draft protocol for the “Enhanced OECD Test Guideline no. 407”

@article{Higashihara2007SubacuteOT,
  title={Subacute oral toxicity study of bisphenol F based on the draft protocol for the “Enhanced OECD Test Guideline no. 407”},
  author={Nobuhiko Higashihara and Keiji Shiraishi and Katusi Miyata and Yutaka Oshima and Yasushi Minobe and Kanji Yamasaki},
  journal={Archives of Toxicology},
  year={2007},
  volume={81},
  pages={825-832}
}
Since bisphenol F (4,4’-dihydroxydiphenylmethane) has been reported to exhibit estrogen agonistic properties in the uterotrophic assay, we performed a 28-day repeated-dose toxicity study (enhanced OECD test guideline No. 407) on bisphenol F based on the OECD draft protocols to determine whether it has endocrine-mediated properties. Bisphenol F was orally administered at doses 0, 20, 100 and 500 mg/kg per day for at least 28 days, but no clear endocrine-mediated changes were detected, and it was… 
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