Subacute necrotizing encephalomyelopathy (Leigh's disease): a clinicopathologic study of ten cases.

@article{Agapitos1997SubacuteNE,
  title={Subacute necrotizing encephalomyelopathy (Leigh's disease): a clinicopathologic study of ten cases.},
  author={Emmanuel B Agapitos and Petros M. Pavlopoulos and Es Patsouris and Panayiotis S. Davaris},
  journal={General & diagnostic pathology},
  year={1997},
  volume={142 5-6},
  pages={335-41}
}
Archival material and clinical data of 10 autopsy cases of Leigh's disease (LS), aged from 44 days to 9 years at death, were reviewed. Development delay, irregular respiration, feeding difficulty, and abnormal eye signs were the most common symptoms. Seizures (five of ten cases) were also frequent. In most patients, the diagnosis of LS was established… CONTINUE READING