Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density.

@article{McClung2016SubacuteLI,
  title={Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density.},
  author={Joseph M. McClung and Timothy J. McCord and Kevin W. Southerland and Cameron A. Schmidt and Michael E Padgett and Terence Edward Ryan and Christopher D. Kontos},
  journal={Journal of vascular surgery},
  year={2016},
  volume={64 4},
  pages={1101-1111.e2}
}
OBJECTIVE The primary preclinical model of peripheral artery disease, which involves acute limb ischemia (ALI), can result in appreciable muscle injury that is attributed to the acuity of the ischemic injury. A less acute model of murine limb ischemia using ameroid constrictors (ACs) has been developed in an attempt to mimic the chronic nature of human… CONTINUE READING