Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: a case report with autopsy examination.

@article{Fukano2000SubacuteHF,
  title={Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: a case report with autopsy examination.},
  author={Masahiro Fukano and Shinji Amano and Junichiro Sato and Kazuhide Yamamoto and Hironobu Adachi and Hidetoshi Okabe and Yoshihide Fujiyama and Tadao Bamba},
  journal={Human pathology},
  year={2000},
  volume={31 2},
  pages={250-3}
}
An autopsy case of fatal subacute hepatic failure after administration of troglitazone is described. The liver dysfunction developed about five months after the patient, a sixty-three-year-old woman, had been initially treated with troglitazone. The patient developed hepatic failure and died despite various hepatic auxiliary treatments such as plasmapheresis. Autopsy findings revealed focal liver cell necrosis, cholestasis and steatosis with infiltration of lymphocytes and neutrophils and lack… CONTINUE READING