Subacute coagulopathy in a randomized, comparative trial of Fab and F(ab')2 antivenoms.

@article{Boyer2013SubacuteCI,
  title={Subacute coagulopathy in a randomized, comparative trial of Fab and F(ab')2 antivenoms.},
  author={Leslie Victoria Boyer and Peter B Chase and Janice A Degan and Gary R. Figge and Alma Buelna-Romero and Cynthia Luchetti and Alejandro Alag{\'o}n},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2013},
  volume={74},
  pages={101-8}
}
BACKGROUND Envenomation by pit vipers is associated with coagulation disorders including hypofibrinogenemia and thrombocytopenia. These abnormalities correct following antivenom treatment during the acute phase of the disease. Delayed or recurrent coagulation abnormalities have been reported following use of Fab antivenom, resulting in risk of hemorrhage or death. METHODS We hypothesized that the longer plasma persistence of F(ab')2 antivenom, relative to Fab, in patients at risk of… CONTINUE READING

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