Subacute (28-day) toxicity of furfural in Fischer 344 rats: a comparison of the oral and inhalation route.

@article{Arts2004SubacuteT,
  title={Subacute (28-day) toxicity of furfural in Fischer 344 rats: a comparison of the oral and inhalation route.},
  author={Josje H. E. Arts and Hans Muijser and Marko J Appel and C Frieke Kuper and Jos G. M. Bessems and Ruud A. Woutersen},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2004},
  volume={42 9},
  pages={1389-99}
}
The subacute oral and inhalation toxicity of furfural vapour was studied in Fischer 344 rats to investigate whether route-to-route extrapolation could be employed to derive the limit value for inhalation exposure from oral toxicity data. Groups of 5 rats per sex were treated by gavage daily for 28 days at dose levels of 6-192 mg/kg bw/day, or exposed by inhalation to concentrations of 20-1280 mg/m3 (6 h/day, 5 days/week) or 160-1280 mg/m3 (3 h/day, 5 days/week) for 28 days. Controls received… CONTINUE READING

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