SubRecon: Ancestral Reconstruction of Amino Acid Substitutions Along a Branch in a Phylogeny.

Abstract

Summary Existing ancestral sequence reconstruction techniques are ill-suited to investigating substitutions on a single branch of interest. We present SubRecon, an implementation of a hybrid technique integrating joint and marginal reconstruction for protein sequence data. SubRecon calculates the joint probability of states at adjacent internal nodes in a… (More)
DOI: 10.1093/bioinformatics/bty101

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