Sub-second kinetics of the nitric oxide receptor, soluble guanylyl cyclase, in intact cerebellar cells.

@article{Bellamy2001SubsecondKO,
  title={Sub-second kinetics of the nitric oxide receptor, soluble guanylyl cyclase, in intact cerebellar cells.},
  author={Tomas C. Bellamy and John Garthwaite},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 6},
  pages={
          4287-92
        }
}
Soluble guanylyl cyclase (sGC) catalyzes cGMP synthesis and serves as a physiological receptor for nitric oxide (NO). Recent evidence indicates that key properties of sGC within cells differ from those of purified sGC. We have devised a technique for resolving NO-stimulated sGC activity in cells on a sub-second time scale, enabling the first quantitative description of the kinetics of the enzyme within its natural environment. Upon release of NO from a caged derivative, sGC became activated… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 39 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-2 OF 2 REFERENCES

Sub-second Kinetics of NO-stimulated Guanylyl Cyclase in Cells 4292 by gest on Sptem er 12

  • J. Wood, J. Garthwaite
  • Neuropharmacology
  • 1994
1 Excerpt

Similar Papers

Loading similar papers…