Sub-nuclear localization of Rad51 in response to DNA damage.

  title={Sub-nuclear localization of Rad51 in response to DNA damage.},
  author={Emil V Mladenov and Boyka B Anachkova and Irina Tsaneva},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={11 5},
The repair of DNA double-strand breaks involves the accumulation of key homologous recombination proteins in nuclear foci at the sites of repair. The organization of these foci in relation to non-chromatin nuclear structures is poorly understood. To address this question, we examined the distribution of several recombination proteins in subcellular fractions following treatment of HeLa cells with ionizing radiation and the crosslinking agent mitomycin C. The results showed association of Rad51… CONTINUE READING


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