Sub-diaphragmatic vagal afferent integration of meal-related gastrointestinal signals.

  title={Sub-diaphragmatic vagal afferent integration of meal-related gastrointestinal signals.},
  author={Gary J Schwartz and Timothy H. Moran},
  journal={Neuroscience and biobehavioral reviews},
  volume={20 1},
We have established a method to investigate the range of mechanical, nutrient chemical and peptidergic meal-related stimuli t hat may generate vagal afferent neurophysiological signals critical to the negative feedback control of food intake in the rat. We have identified populations of fibers that respond with increased neurophysiological discharge rates to gastric loads, duodenal loads, and close celiac arterial administration of a brain-gut peptide, cholecystokinin. Load-sensitive fibers… CONTINUE READING

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