Sub-cellular targeting of constitutive NOS in health and disease.

Abstract

Constitutive nitric oxide synthases (NOSs) are ubiquitous enzymes that play a pivotal role in the regulation of myocardial function in health and disease. The discovery of both a neuronal NOS (nNOS) and an endothelial NOS (eNOS) isoform in the myocardium and the availability of genetically modified mice with selective eNOS or nNOS gene deletion have been of… (More)
DOI: 10.1016/j.yjmcc.2011.09.006

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