Sub-cellular distribution of UNC-104(KIF1A) upon binding to adaptors as UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-α) in C. elegans neurons.

@article{Hsu2011SubcellularDO,
  title={Sub-cellular distribution of UNC-104(KIF1A) upon binding to adaptors as UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-α) in C. elegans neurons.},
  author={C-C Hsu and J D Moncaleano and Oliver Ingvar Wagner},
  journal={Neuroscience},
  year={2011},
  volume={176},
  pages={39-52}
}
The accumulation of cargo (tau, amyloid precursor protein, neurofilaments etc.) in neurons is a hallmark of various neurodegenerative diseases while we have only little knowledge how axonal transport is regulated. Kinesin-3 UNC-104(KIF1A) is the major transporter of synaptic vesicles and recent reports suggest that a cargo itself can affect the motor's activity. Inspecting an interactome map, we identify three putative UNC-104 interactors, namely UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2… CONTINUE READING

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regulated by a presynaptic MALS/Liprin-alpha protein complex

  • R Sakamoto, DT Byrd, HM Brown, N Hisamoto, K Matsumoto, Y Jin
  • Curr Opin Cell Biol
  • 2005
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