Sub-angstrom conformational changes of a single molecule captured by AFM variance analysis.

@article{Walther2006SubangstromCC,
  title={Sub-angstrom conformational changes of a single molecule captured by AFM variance analysis.},
  author={Kirstin A. Walther and Jasna Bruji{\'c} and Hongbin Li and J. M. Fern{\'a}ndez},
  journal={Biophysical journal},
  year={2006},
  volume={90 10},
  pages={3806-12}
}
A system's equilibrium variance can be analyzed to probe its underlying dynamics at higher resolution. Here, using single-molecule atomic-force microscope techniques, we show how the variance in the length of a single dextran molecule can be used to establish thermodynamic equilibrium and to detect conformational changes not directly observable with other methods. Dextran is comprised of a chain of pyranose rings that each undergoes an Angstrom-scale transition from a chair to boat conformation… CONTINUE READING

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