Corpus ID: 28792652

Sub-Saharan African randomised clinical trials into male circumcision and HIV transmission: methodological, ethical and legal concerns.

@article{Boyle2011SubSaharanAR,
  title={Sub-Saharan African randomised clinical trials into male circumcision and HIV transmission: methodological, ethical and legal concerns.},
  author={G. Boyle and G. Hill},
  journal={Journal of law and medicine},
  year={2011},
  volume={19 2},
  pages={
          316-34
        }
}
  • G. Boyle, G. Hill
  • Published 2011
  • Medicine
  • Journal of law and medicine
  • In 2007, WHO/UNAIDS recommended male circumcision as an HIV-preventive measure based on three sub-Saharan African randomised clinical trials (RCTs) into female-to-male sexual transmission. A related RCT investigated male-to-female transmission. However, the trials were compromised by inadequate equipoise; selection bias; inadequate blinding; problematic randomisation; trials stopped early with exaggerated treatment effects; and not investigating non-sexual transmission. Several questions remain… CONTINUE READING

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