Sub-Chronic Toxicity Study of Fixed Dose Combination of Ofloxacin- Ornidazole in Mus Musculus Mice

@article{Chaudhary2009SubChronicTS,
  title={Sub-Chronic Toxicity Study of Fixed Dose Combination of Ofloxacin- Ornidazole in Mus Musculus Mice},
  author={Manu Chaudhary and Anupama Tamta and Rajesh Sehgal},
  journal={The Open Toxicology Journal},
  year={2009},
  volume={3},
  pages={24-29}
}
The present study investigated safety/toxicity profile of fixed dose combination of Ofloxacin-Ornidazole injec- tion in Mus musculus mice at three dose levels, ranging from asymptomatic to high dose. To enhance the antimicrobial spectrum of the quinolones against anaerobic organisms and gram positive bacteria, fixed dose combination of Ofloxacin and Ornidazole injection was introduced. It has been found highly effective as well as synergistic and has the potential of usage for empirical therapy… 

Tables from this paper

Fluoroquinolones Reported Hepatotoxicity
TLDR
Most clinically used fluoroquinolones are relatively safe but Clinicians should consider patients liver function status before fluoroquolones clinical recommendation and in some cases biochemical parameters associated with liver function should be monitored in patients with impaired liver function.
Composition parentérale comprenant un composé fluoroquinolone et un composé nitroimidazole
La presente invention porte sur de nouvelles compositions parenterales comprenant au moins un compose fluoroquinolone et au moins un compose nitroimidazole. L'invention porte en outre sur des

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