Styryl lactones and their derivatives: biological activities, mechanisms of action and potential leads for drug design.

@article{deFtima2006StyrylLA,
  title={Styryl lactones and their derivatives: biological activities, mechanisms of action and potential leads for drug design.},
  author={{\^A}ngelo de F{\'a}tima and Luzia Valentina Modolo and Leila de Souza Conegero and Ronaldo Aloise Pilli and Carmen Ver{\'i}ssima Ferreira and Luciana Konecny Kohn and Jo{\~a}o Ernesto de Carvalho},
  journal={Current medicinal chemistry},
  year={2006},
  volume={13 28},
  pages={
          3371-84
        }
}
Nature is an inexhaustible source of natural compounds with interesting biological activities. In general, natural products are an important source of new compounds with a variety of structural arrangements and singular properties. Styryl lactones are a group of secondary metabolites ubiquitous in the genus Goniothalamus that have demonstrated to possess interesting biological properties, in particular antiproliferative activity against cancer cells. In general, the cytotoxicity of styryl… 
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This review covers the chemistry and biological aspects of goniothalamin-related styryl lactones isolated from natural sources and the reports on the synthesis, biological activity and mechanism of action which were published from 2007-2017.
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