Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450.

@article{Nakajima1994StyreneMB,
  title={Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450.},
  author={T. Nakajima and E. Elovaara and F. Gonzalez and H. Gelboin and H. Raunio and O. Pelkonen and H. Vainio and T. Aoyama},
  journal={Chemical research in toxicology},
  year={1994},
  volume={7 6},
  pages={
          891-6
        }
}
The rate of formation of styrene glycol from styrene was compared in human, rat, and mouse liver microsomes. At a low styrene concentration (0.085 mM), the rates decreased in the order, mouse (2.43 +/- 0.29 nmol/(mg of protein.min)) > rat (1.07 +/- 0.20) > human (0.73 +/- 0.45); at a high concentration (1.85 mM), the order was rat (4.21 +/- 0.72) > mouse (2.72 +/- 0.11) > human (1.91 +/- 0.84). Kinetic analysis indicated the presence of at least two forms of styrene-metabolizing cytochrome… Expand
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