Styrene induced alterations in biomarkers of exposure and effects in the cochlea: mechanisms of hearing loss.

@article{Chen2007StyreneIA,
  title={Styrene induced alterations in biomarkers of exposure and effects in the cochlea: mechanisms of hearing loss.},
  author={Guang-di Chen and Lai-Har Chi and Paul J. Kostyniak and Donald K. Henderson},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2007},
  volume={98 1},
  pages={167-77}
}
It is known that styrene is ototoxic and causes cochlear damage starting from the middle turn. However, the cellular mechanism underlying styrene ototoxicity is still unclear. In this study, rats were exposed to styrene by gavage at different doses once a day for varying periods. Styrene levels in the cochlear tissues, styrene-induced permanent hearing loss, cochlear disruptions, and cell death pathways were determined. Styrene concentration in the cochlea varied along with the basilar membrane… CONTINUE READING

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