Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp.

@article{Arai2012StylissamideXA,
  title={Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp.},
  author={Masayoshi Arai and Yoshiwo Yamano and Mayumi Fujita and Andi Setiawan and Motomasa Kobayashi},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2012},
  volume={22 4},
  pages={
          1818-21
        }
}
Reniochalistatins A-E, cyclic peptides from the marine sponge Reniochalina stalagmitis.
TLDR
The cyclic octapeptide reniochalistatin E showed biological activity in various cytotoxicity assays employing different tumor cell lines (RPMI-8226, MGC-803, HL-60, HepG2, and HeLa).
Stylissamide X (I), a New Proline-Rich Cyclic Octapeptide as an Inhibitor of Cell Migration, from an Indonesian Marine Sponge of Stylissa sp.
TLDR
In conclusion,olation, structure elucidation and screening of inhibitory activity against migration of HeLa cells is described as a “breakthrough” in the efforts to understand the “why and how” of cell reprograming.
Structures and Solution Conformational Dynamics of Stylissamides G and H from the Bahamian Sponge Stylissa caribica
TLDR
Two new peptides, stylissamides G and H, were isolated from extracts of a sample of Stylissa caribica collected in deep waters of the Caribbean Sea and solved by integrated analysis of the MS and NMR spectra and chemical degradation.
First Total Synthesis and Biological Screening of a Proline-Rich Cyclopeptide from a Caribbean Marine Sponge
TLDR
Results of pharmacological activity studies indicated that the newly synthesized cycloheptapeptide displayed good anthelmintic potential against Megascoplex konkanensis, Pontoscotex corethruses and Eudrilus eugeniea and potent antifungal activity against pathogenic Candida albicans and dermatophytes Trichophyton mentagrophytes and Microsporum audouinii at a concentration of 6 μg/mL.
Sequencing of cyclic peptides by NMR and MS techniques demonstrated on stylissamides A–F
TLDR
The elucidation of the structures of stylissamides 1–6 by a combination of NMR and mass spectrometry (MS/MS and MSn experiments) is reviewed.
Cyclopeptides from the Sponge Stylissa flabelliformis.
TLDR
Three new cyclopeptides, phakellistatins 20-22 (1-3), as well as 10 known cyclopes of the same structural class were isolated from the tropical sponge Stylissa flabelliformis and evaluated for in vitro cytotoxicity against a variety of cancer cell lines.
Total Synthesis of Proline-Rich Cyclic Octapeptide Stylissamide X
The naturally occurring proline-rich cyclic octapeptide stylissamide X is for the first time total synthesized in the present study by a two-step solid-phase/solution synthesis strategy using two
New Tricks with an Old Sponge: Feature-Based Molecular Networking Led to Fast Identification of New Stylissamide L from Stylissa caribica
TLDR
Feature-based molecular networking was used to re-examine the secondary metabolites in extracts of a very well studied marine sponge, Stylissa caribica, and revealed the presence of 13 cyclic peptides in the sponge that had never been detected in previous work and appeared to be new compounds.
...
1
2
3
4
...

References

SHOWING 1-10 OF 25 REFERENCES
Isolation and structure of stylostatin 1 from the Papua New Guinea marine sponge Stylotella aurantium
A new cell growth inhibitory (P388 lymphocytic leukemia ED 50 0.8 μg/mL) cycloheptapeptide designated stylostatin 1 (1) has been isolated from the south Pacific Ocean sponge Stylotella aurantium
Isolation and structure of the marine sponge cell growth inhibitory cyclic peptide phakellistatin 1.
TLDR
A new cell growth inhibitory cycloheptapeptide designated phakellistatin 1 was isolated from two Indo-Pacific sponges, Phakellia costata and Stylotella aurantium, and this assignment was finally confirmed by an X-ray crystal structure determination.
Stylissamides A-D - New Proline-Containing Cyclic Heptapeptides from the Marine Sponge Stylissa caribica
Four new cyclic heptapeptides, stylissamides A–D (1–4), were isolated from the Caribbean sponge Stylissa caribica. The structures of these metabolites were elucidated by NMR and MS/MS methods. The
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
TLDR
Two new cyclic heptapeptides were isolated and characterized from the Jamaican sponge Stylissa caribica, in addition to the known bromopyrrole alkaloids sceptrin, stevensine, and oroidin, which have been evaluated for their antimicrobial, antimalarial, anticancer,anti-HIV-1, anti-Mtb, and antiinflammatory activities.
Tawicyclamides A and B, new cyclic peptides from the Ascidian Lissoclinum patella: studies on the solution- and solid-state conformations
Two new cytotoxic cyclic peptides, tawicyclamides A and B (1-2), were isolatedfrom the ascidian Lissoclinum patella collected in the Philippine Islands and their structures determined byNMR
Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities.
TLDR
Migrastatin inhibited spontaneous migration of human esophageal cancer EC17 cells and migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.
Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from Phakellia sp.
TLDR
Two new marine sponge constituents, phakellistatin 10 and 11, were found to be cyclic octapeptides that significantly inhibited growth of the murine P-388 lymphocytic leukemia and human cancer cell lines.
...
1
2
3
...