Stx1 prophage excision in Escherichia coli strain PA20 confers strong curli and biofilm formation by restoring native mlrA.

@article{Uhlich2016Stx1PE,
  title={Stx1 prophage excision in Escherichia coli strain PA20 confers strong curli and biofilm formation by restoring native mlrA.},
  author={Gaylen A Uhlich and Chin-Yi Chen and Bryan J. Cottrell and Christopher S. Hofmann and Xianghe Yan and Ly A Nguyen},
  journal={FEMS microbiology letters},
  year={2016},
  volume={363 13}
}
Prophage insertions in Escherichia coli O157:H7 mlrA contribute to the low expression of curli fimbriae and biofilm observed in many clinical isolates. Varying levels of CsgD-dependent curli/biofilm expression are restored to strains bearing prophage insertions in mlrA by mutation of regulatory genes affecting csgD Our previous study identified strong biofilm- and curli-producing variants in O157:H7 cultures that had lost the mlrA-imbedded prophage characteristic of the parent population… CONTINUE READING
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