Studying the structure and regulation of soluble guanylyl cyclase.

@article{Koesling1999StudyingTS,
  title={Studying the structure and regulation of soluble guanylyl cyclase.},
  author={Doris Koesling},
  journal={Methods},
  year={1999},
  volume={19 4},
  pages={485-93}
}
Soluble guanylyl cyclase acts as the receptor for the signaling molecule nitric oxide. The enzyme consists of two different subunits. Each subunit shows the cyclase catalytic domain, which is also conserved in the membrane-bound guanylyl cyclases and the adenylyl cyclases. The N-terminal regions of the subunits are responsible for binding of the prosthetic heme group of the enzyme, which is required for the stimulatory effect of nitric oxide (NO). The five-coordinated ferrous heme displays a… CONTINUE READING