Studying the effects of matrix stiffness on cellular function using acrylamide-based hydrogels.

@article{Cretu2010StudyingTE,
  title={Studying the effects of matrix stiffness on cellular function using acrylamide-based hydrogels.},
  author={Alexandra Cretu and Paola Castagnino and Richard K. Assoian},
  journal={Journal of visualized experiments : JoVE},
  year={2010},
  volume={42}
}
Tissue stiffness is an important determinant of cellular function, and changes in tissue stiffness are commonly associated with fibrosis, cancer and cardiovascular disease. Traditional cell biological approaches to studying cellular function involve culturing cells on a rigid substratum (plastic dishes or glass coverslips) which cannot account for the effect of an elastic ECM or the variations in ECM stiffness between tissues. To model in vivo tissue compliance conditions in vitro, we and… CONTINUE READING
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