Studying the CCN Proteins in Fibrosis.

  title={Studying the CCN Proteins in Fibrosis.},
  author={James Hutchenreuther and Andrew Leask and Katherine Thompson},
  journal={Methods in molecular biology},
CCN2 is a profibrotic matricellular protein. CCN2 directly promotes cell adhesion and indirectly promotes fibrosis by activating adhesive signaling in response to growth factors, cytokines, and extracellular matrix. The following protocols will allow the direct assessment of other CCN family members in these processes.