Studying molecular motor-based cargo transport: what is real and what is noise?

  title={Studying molecular motor-based cargo transport: what is real and what is noise?},
  author={D. Petrov and Roop Mallik and George T. Shubeita and Michael Vershinin and Steven P. Gross and Clare C. Yu},
  journal={Biophysical journal},
  volume={92 8},
Noise is a major problem in analyzing tracking data of cargos moved by molecular motors. We use Bayesian statistics to incorporate what is known about the noise in parsing the trajectory of a cargo into a series of constant velocity segments. Tracks with just noise and no underlying motion are fit with constant velocity segments to produce a calibration curve of fit quality versus average segment duration. Fits to tracks of moving cargos are compared to the calibration curves with similar noise… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 18 extracted citations

Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 3 Excerpts


Publications referenced by this paper.
Showing 1-10 of 23 references

Evaluation of models for microtubule-based intracellular bi-directional transport

J. E. Martines
PhD thesis • 2006

Fast vesicle transport inpc 12 neurites : velocities and forces

I. Zaliapin, I. Semenova, A. Kashina, V. Rodionov
Eur . Biophys . J . • 2005

Similar Papers

Loading similar papers…