Studying molecular motor-based cargo transport: what is real and what is noise?

@article{Petrov2007StudyingMM,
  title={Studying molecular motor-based cargo transport: what is real and what is noise?},
  author={D. Petrov and Roop Mallik and George T. Shubeita and Michael Vershinin and Steven P. Gross and Clare C. Yu},
  journal={Biophysical journal},
  year={2007},
  volume={92 8},
  pages={2953-63}
}
Noise is a major problem in analyzing tracking data of cargos moved by molecular motors. We use Bayesian statistics to incorporate what is known about the noise in parsing the trajectory of a cargo into a series of constant velocity segments. Tracks with just noise and no underlying motion are fit with constant velocity segments to produce a calibration curve of fit quality versus average segment duration. Fits to tracks of moving cargos are compared to the calibration curves with similar noise… CONTINUE READING

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