Studying mechanosensitive ion channels using liposomes.

Abstract

Mechanosensitive (MS) ion channels are the primary molecular transducers of mechanical force into electrical and/or chemical intracellular signals in living cells. They have been implicated in innumerable mechanosensory physiological processes including touch and pain sensation, hearing, blood pressure control, micturition, cell volume regulation, tissue growth, or cellular turgor control. Much of what we know about the basic physical principles underlying the conversion of mechanical force acting upon membranes of living cells into conformational changes of MS channels comes from studies of MS channels reconstituted into artificial liposomes. Using bacterial MS channels as a model, we have shown by reconstituting these channels into liposomes that there is a close relationship between the physico-chemical properties of the lipid bilayer and structural dynamics bringing about the function of these channels.

DOI: 10.1007/978-1-60761-447-0_4

Statistics

02040201220132014201520162017
Citations per Year

66 Citations

Semantic Scholar estimates that this publication has 66 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Martinac2010StudyingMI, title={Studying mechanosensitive ion channels using liposomes.}, author={Boris Martinac and Paul Rohde and Andrew R. Battle and Evgeny Petrov and Prithwish Pal and Alexander Fook Foo and Valeria V{\'a}squez and Thuan Huynh and Anna Kloda}, journal={Methods in molecular biology}, year={2010}, volume={606}, pages={31-53} }