Studying mechanosensitive ion channels using liposomes.


Mechanosensitive (MS) ion channels are the primary molecular transducers of mechanical force into electrical and/or chemical intracellular signals in living cells. They have been implicated in innumerable mechanosensory physiological processes including touch and pain sensation, hearing, blood pressure control, micturition, cell volume regulation, tissue growth, or cellular turgor control. Much of what we know about the basic physical principles underlying the conversion of mechanical force acting upon membranes of living cells into conformational changes of MS channels comes from studies of MS channels reconstituted into artificial liposomes. Using bacterial MS channels as a model, we have shown by reconstituting these channels into liposomes that there is a close relationship between the physico-chemical properties of the lipid bilayer and structural dynamics bringing about the function of these channels.

DOI: 10.1007/978-1-60761-447-0_4


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@article{Martinac2010StudyingMI, title={Studying mechanosensitive ion channels using liposomes.}, author={Boris Martinac and Paul Rohde and Andrew R. Battle and Evgeny Petrov and Prithwish Pal and Alexander Fook Foo and Valeria V{\'a}squez and Thuan Huynh and Anna Kloda}, journal={Methods in molecular biology}, year={2010}, volume={606}, pages={31-53} }