Studying isoform-specific inositol 1,4,5-trisphosphate receptor function and regulation.

  title={Studying isoform-specific inositol 1,4,5-trisphosphate receptor function and regulation.},
  author={Matthew J. Betzenhauser and Larry E. Wagner and Jong Hak Won and David I. Yule},
  volume={46 3},
Inositol 1,4,5-trisphosphate receptors (InsP3R) are a family of ubiquitously expressed intracellular Ca2+ channels. Isoform-specific properties of the three family members may play a prominent role in defining the rich diversity of the spatial and temporal characteristics of intracellular Ca2+ signals. Studying the properties of the particular family members is complicated because individual receptor isoforms are typically never expressed in isolation. In this article, we discuss strategies for… CONTINUE READING

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