Studying gene function in eukaryotes by conditional gene inactivation.

@article{Gossen2002StudyingGF,
  title={Studying gene function in eukaryotes by conditional gene inactivation.},
  author={Manfred Gossen and Hermann Bujard},
  journal={Annual review of genetics},
  year={2002},
  volume={36},
  pages={
          153-73
        }
}
The prospect of specifically controlling gene activities in vivo has become a defining hallmark of many model organisms of biological research. Where once the aim was to gain control over gene activities using endogenous control elements, new technologies have emerged that owe their remarkable specificity to heterologous components derived from evolutionarily distant species. This review highlights inducible transcriptional systems and site-specific recombination. Their quantitative and… CONTINUE READING
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