Studying TGF-beta superfamily signaling by knockouts and knockins.

  title={Studying TGF-beta superfamily signaling by knockouts and knockins.},
  author={Hua Chang and A L Lau and Martin M. Matzuk},
  journal={Molecular and cellular endocrinology},
  volume={180 1-2},
The transforming growth factor beta (TGF-beta) superfamily has profound effects on many aspects of animal development. In the last decade, our laboratory and others have performed in vivo functional studies on multiple components of the TGF-beta superfamily signal transduction pathway, including upstream ligands, transmembrane receptors, receptor-associated proteins and downstream Smad proteins. We have taken gene knockout approaches to generate null alleles of the genes of interest, as well as… CONTINUE READING


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