Corpus ID: 73810399

Studying Human Leukemic Stem Cells in Mice

  title={Studying Human Leukemic Stem Cells in Mice},
  author={Mine and Harada},
  • Mine, Harada
  • Published 2007
  • Medicine
  • Transplantation of human leukemic cells into severe combined immunodeficiency(SCID)mice has been attempted to study leukemogenesis and to develop therapeuticmodalities.Previous models,however,were limited in efficient initiation orlong-term engraftment of leukemic cells following the transplantation of primaryhuman leukemic cells.The insufficient engraftment of primary leukemic cells couldbe caused by the residual innate immunity in CB-17/SCID or NOD/SCID mice.We thus 

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