Studying Human Leukemic Stem Cells in Mice
@inproceedings{Mine2007StudyingHL,
title={Studying Human Leukemic Stem Cells in Mice},
author={Mine and Harada},
year={2007}
}Transplantation of human leukemic cells into severe combined immunodeficiency(SCID)mice has been attempted to study leukemogenesis and to develop therapeuticmodalities.Previous models,however,were limited in efficient initiation orlong-term engraftment of leukemic cells following the transplantation of primaryhuman leukemic cells.The insufficient engraftment of primary leukemic cells couldbe caused by the residual innate immunity in CB-17/SCID or NOD/SCID mice.We thus