Study to compare the enzyme activity, acid resistance and dissolution characteristics of currently available pancreatic enzyme preparations

@article{Whitehead2005StudyTC,
  title={Study to compare the enzyme activity, acid resistance and dissolution characteristics of currently available pancreatic enzyme preparations},
  author={A M Whitehead},
  journal={Pharmaceutisch Weekblad},
  year={2005},
  volume={10},
  pages={12-16}
}
  • A. Whitehead
  • Published 19 February 1988
  • Chemistry, Medicine
  • Pharmaceutisch Weekblad
Anin vitro study of currently available pancreatic enzyme preparations was carried out to compare the three main types of product available, these being simple pancreatin preparations, enteric coated tablets and enteric coated granules. Two products from each of these types were analysed to compare their enzyme contents. The enteric coated preparations were tested for acid resistance and their pH dissolution profiles were also investigated. The measured enzyme contents were generally higher… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
Enzyme Replacement Therapy of Exocrine Pancreatic Insufficiency in Man
TLDR
Lipase activity in vitro correlated with potency in vivo for tablet and capsules, with tablets and capsules being effective in reducing steatorrhea by 56.1±9 per cent and 48.6±10 per cent. Expand
Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency.
TLDR
Cimetidine may be a useful adjunct to oral pancreatic extract therapy in some patients with severe pancreatic insufficiency who fail to respond to pancreatic enzyme replacement alone. Expand
Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dosage schedules.
TLDR
Prandial was as effective as hourly administration in decreasing steatorrhea and perhaps more effective in abolishing azotorrhea, and since it is also more convenient, it is recommend it. Expand
Pancreatic enzyme replacement
  • D. Graham
  • Chemistry, Medicine
  • Digestive Diseases and Sciences
  • 2005
TLDR
Intraduodenal lipase activity following test meals was found to be a poor predictor of the effectiveness of antacid therapy in improving the efficacy of supplemental enzymes. Expand
Lingual lipase in cystic fibrosis. Quantitation of enzyme activity in the upper small intestine of patients with exocrine pancreatic insufficiency.
TLDR
The data presented show that lingual lipase remains fully active in CF and accounts for greater than 90% of total lipase activity in the upper small intestine, and suggest that, because of low intestinal pH in CF, enzyme replacement therapy containing linguallipase could improve fat absorption in CF patients to a greater extent than the pancreatic preparations now in use. Expand
Comparative Trial of Pancrex V Forte and Nutrizym in Treatment of Malabsorption in Cystic Fibrosis
TLDR
Though there was no laboratory evidence to support their choice nine patients expressed a preference for Nutrizym at the conclusion of the trial, based partly on the smaller number of tablets which are required. Expand
Influence of exocrine pancreatic insufficiency on the intraluminal pH of the proximal small intestine
TLDR
Data indicate that patients with significant exocrine pancreatic disease have an acidic milieu in the upper small intestine both under fasting as well as under postprandial conditions. Expand
Steatorrhea and azotorrhea and their relation to growth and nutrition in adolescents and young adults with cystic fibrosis.
TLDR
It was concluded that despite pancreatic deficiency most older patients with CF need little dietary restriction, although treatment should be individualized. Expand
Exocrine pancreatic function tests.
TLDR
The purpose of this progress report is to discuss current exocrine pancreatic function tests with special reference to their practicability, to state whether these tests are able to differentiate between impairment of pancreaticfunction of diverse aetiology, and to suggest possible ways of refining tubeless tests. Expand
A prospective comparison of current diagnostic tests for pancreatic cancer.
TLDR
Endoscopic retrograde pancreatography and arteriography were significantly more sensitive than cytologic study in diagnosis of pancreatic cancer and abdominal ultrasound should be performed first, and if it is negative, a pancreatic-function test next. Expand
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