Study to compare the enzyme activity, acid resistance and dissolution characteristics of currently available pancreatic enzyme preparations

  title={Study to compare the enzyme activity, acid resistance and dissolution characteristics of currently available pancreatic enzyme preparations},
  author={A M Whitehead},
  journal={Pharmaceutisch Weekblad},
  • A. Whitehead
  • Published 19 February 1988
  • Medicine, Biology, Chemistry
  • Pharmaceutisch Weekblad
Anin vitro study of currently available pancreatic enzyme preparations was carried out to compare the three main types of product available, these being simple pancreatin preparations, enteric coated tablets and enteric coated granules. Two products from each of these types were analysed to compare their enzyme contents. The enteric coated preparations were tested for acid resistance and their pH dissolution profiles were also investigated. The measured enzyme contents were generally higher… 

In Vitro Comparison of Physical Parameters, Enzyme Activity, Acid Resistance, and pH Dissolution Characteristics of Enteric-Coated Pancreatic Enzyme Preparations: Implications for Clinical Variability and Pharmacy Substitution.

The in vitro variability of key performance parameters among a representative group of currently available pancreatic enzyme formulations with pharmaceutically equivalent labels is investigated and confirms the existence of "branded"-to-"generic," product-to-product, and batch- to-batch variability.

In vitro comparative study of three pancreatic enzyme preparations: dissolution profiles, active enzyme release and acid stability

This data indicates that polypeptide A, which is commonly used for the treatment of pancreatic insufficiency, is ineligible for use in clinical practice because of its low bioequivalence with other pancreatic enzyme preparations.

Study of the gastrointestinal bioavailability of a pancreatic extract product (Zenpep) in chronic pancreatitis patients with exocrine pancreatic insufficiency.

Pancreatic enzyme-replacement therapy in CF: considerations for the USA

  • J. Heubi
  • Medicine
    Expert review of respiratory medicine
  • 2008
Clinical studies are currently underway to demonstrate the safety and efficacy of different PEPs, including new formulations that meet FDA guidelines for no enzyme overfill.


This study is investigation of tableting compression behaviour of protein pharmaceutical in tablet formulations by the use of trypsin–chymotrypsin s as model drug. The trypsin‐chymotrypsin mixture

Gastric Transit and Pharmacodynamics of a Two-Millimeter Enteric-Coated Pancreatin Microsphere Preparation in Patients with Chronic Pancreatitis

In chronic pancreatitis, a 2-mm ECPM preparation does not pass through the stomach more slowly than a solid meal, but in fact faster, and Digestion of ester lipids and proteins showed animprovement to subnormal and normal levels,respectively.

Enzyme Contents of Pancreatic Extract Preparations

Exogenous pancreatic enzyme supplementation may be required in a variety of inherited pancreatic insufficiency conditions, including cystic fibrosis (CF) and Schwachman syndrome, and after surgical

International phase III trial of liprotamase efficacy and safety in pancreatic-insufficient cystic fibrosis patients.

Bio-Inspired Polymer Membrane Surface Cleaning

To generate polyethersulfone membranes with a biocatalytically active surface, pancreatin was covalently immobilized and the resulting membranes exhibit self-cleaning properties after “switching on” the respective enzyme by adjusting pH and temperature.



Enzyme Replacement Therapy of Exocrine Pancreatic Insufficiency in Man

Lipase activity in vitro correlated with potency in vivo for tablet and capsules, with tablets and capsules being effective in reducing steatorrhea by 56.1±9 per cent and 48.6±10 per cent.

Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency.

Cimetidine may be a useful adjunct to oral pancreatic extract therapy in some patients with severe pancreatic insufficiency who fail to respond to pancreatic enzyme replacement alone.

Fate of orally ingested enzymes in pancreatic insufficiency. Comparison of two dosage schedules.

Prandial was as effective as hourly administration in decreasing steatorrhea and perhaps more effective in abolishing azotorrhea, and since it is also more convenient, it is recommend it.

Pancreatic enzyme replacement

  • D. Graham
  • Medicine
    Digestive Diseases and Sciences
  • 2005
Intraduodenal lipase activity following test meals was found to be a poor predictor of the effectiveness of antacid therapy in improving the efficacy of supplemental enzymes.

Lingual lipase in cystic fibrosis. Quantitation of enzyme activity in the upper small intestine of patients with exocrine pancreatic insufficiency.

The data presented show that lingual lipase remains fully active in CF and accounts for greater than 90% of total lipase activity in the upper small intestine, and suggest that, because of low intestinal pH in CF, enzyme replacement therapy containing linguallipase could improve fat absorption in CF patients to a greater extent than the pancreatic preparations now in use.

Comparative Trial of Pancrex V Forte and Nutrizym in Treatment of Malabsorption in Cystic Fibrosis

Though there was no laboratory evidence to support their choice nine patients expressed a preference for Nutrizym at the conclusion of the trial, based partly on the smaller number of tablets which are required.

Influence of exocrine pancreatic insufficiency on the intraluminal pH of the proximal small intestine

Data indicate that patients with significant exocrine pancreatic disease have an acidic milieu in the upper small intestine both under fasting as well as under postprandial conditions.

Exocrine pancreatic function tests.

The purpose of this progress report is to discuss current exocrine pancreatic function tests with special reference to their practicability, to state whether these tests are able to differentiate between impairment of pancreaticfunction of diverse aetiology, and to suggest possible ways of refining tubeless tests.

A prospective comparison of current diagnostic tests for pancreatic cancer.

Endoscopic retrograde pancreatography and arteriography were significantly more sensitive than cytologic study in diagnosis of pancreatic cancer and abdominal ultrasound should be performed first, and if it is negative, a pancreatic-function test next.

The ins and outs of oral pancreatic enzymes.

  • J. H. Meyer
  • Medicine
    The New England journal of medicine
  • 1977
Treating pancreatic exocrine insufficiency with orally administered pancreatic enzymes is more difficult than is usually imagined.1 The goals of therapy are to prevent weight loss and muscle wastin...