Study on the mechanism of Giardia lamblia induced diarrhoea in mice.

@article{Gorowara1992StudyOT,
  title={Study on the mechanism of Giardia lamblia induced diarrhoea in mice.},
  author={S Gorowara and Nirmal Kumar Ganguly and Ramesh Chander Mahajan and Brij N S Walia},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1138 2},
  pages={122-6}
}
The transmucosal fluxes of Na+ and Cl- were studied in Giardia lamblia infected mice in the presence or absence of phorbol-12-myristate-13-acetate (PMA), the activator of protein kinase C (PKC) or 1-(5-isoquinolinylsulphonyl)-2-methylpiperazine (H-7), the inhibitor of PKC or Ca(2+)-calmodulin. There was net secretion of Na+ and Cl- in infected animals, while in control animals there was net absorption of these ions. The addition of ionophore or PMA resulted in net secretion of Na+ and Cl- in… CONTINUE READING

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