Study on the intestinal absorption profiles of tanshinone IIA and its inclusion complex with cyclodextrin in rats.

@article{Wang2009StudyOT,
  title={Study on the intestinal absorption profiles of tanshinone IIA and its inclusion complex with cyclodextrin in rats.},
  author={Ling Wang and Yan Lai and Chenrui Li and Xuehua Jiang},
  journal={PDA journal of pharmaceutical science and technology},
  year={2009},
  volume={63 5},
  pages={390-400}
}
In this paper, the effect of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) on the intestinal permeability of the tanshinone IIA (TS) was investigated. The inclusion complex was obtained at the molar ratio of 1:1 by lyophilization and characterized by differential scanning calorimetry and phase solubility studies. Using the in situ intestinal perfusion technique, the absorption behaviors of TS and its inclusion complex were investigated at a series of concentration levels in three separate… CONTINUE READING

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