Study on the bone marrow mesenchymal stem cells induced drug resistance in the U937 cells and its mechanism.

  title={Study on the bone marrow mesenchymal stem cells induced drug resistance in the U937 cells and its mechanism.},
  author={Yu-mei Lin and Gui-zhen Zhang and Zong-xiang Leng and Zhen-xia Lu and Li-sha Bu and Shen Gao and Shao-juan Yang},
  journal={Chinese medical journal},
  volume={119 11},
BACKGROUND The hematopoietic microenvironment (HM) plays a critical role in malignant cell growth, patient survival, and response to chemotherapy in hematologic malignancies. However, mechanisms associated with this environmental influence remain unclear. In this study, we investigated the role of bone marrow derived mesenchymal stem cells (MSCs) in U937 cell line, to find out the relations between leukemia drug resistance and the MSCs. METHODS U937 cells were cultured in suspension or grew… 

Effects of Hypoxia on Biology of Human Leukemia T-cell Line (MOLT-4 cells) Co-cultured with Bone Marrow Mesenchymal Stem Cells

The results indicated that this condition significantly increases the expression of BCL2 and reduces the apoptosis in MOLT-4 cells co-cultured with MSCs in the hypoxic condition, which can demonstrate the important role of hypoxia and M SCs on the biological behavior of Acute Lymphoblastic Leukemia cells that may lead to particular treatment outcomes.

The Effect of Bone Marrow Mesenchymal Stem Cells on Vitamin D3 Induced Monocytic Differentiation of U937 Cells.

The results obtained show that MSCs have supportive effect on the monocytic differentiation of U937 cells, however, a distinct mechanism of that remains unclear.

Mesenchymal stem cells show functional defect and decreased anti-cancer effect after exposure to chemotherapeutic drugs

Chemotherapeutic drug treatment altered the phenotype, osteogenic and adipogenic differentiation potential of MSC and modified the gene expression profile of the cells to render them more chemoprotective of the leukemic cells.

The Effects of Hypoxia on U937 Cell Line in Mesenchymal Stem Cells Co-Culture System.

It is demonstrated that MSCs should be regarded as an important member of BM milieu in several clinical applications such as BM transplantation prognosis and treatment of hematologic malignancies.

Influence of Mesenchymal Stem Cells Conditioned Media on Proliferation of Urinary Tract Cancer Cell Lines and Their Sensitivity to Ciprofloxacin

Significantly increased resistance to tested drug indicates that MSCs may protect cancer cells from chemotherapy, and influence of mesenchymal stem cell conditioned media (MSC‐CM) on cancer cells sensitivity to ciprofloxacin is analyzed.

Role of mesenchymal stem cells in leukaemia: Dr. Jekyll or Mr. Hyde?

The key issues in the therapeutic value as well as the harmful effects of the MSCs in leukaemia are addressed with a sharp focus on the recent updates in the published literature.

Electrically-enhanced proliferation control of cancer-stem-cells-like adult human mesenchymal stem cells – a novel modality of treatment

The results indicate that electrical pulses-based therapy could be utilized economically and efficiently to control the proliferation of hMSCs and shows promise of an easy transition to use in the clinic.

Neurogenic Differentiation of Bone Marrow-derived Mesenchymal Stem Cells Using Neural Induction Medium: A Morphological and Histochemical Study

MSCs isolated from bone marrow aspirate can be differentiated into GFAP positive neural cells and show morphological changes consistent with neurogenesis, positive GFAP and nestin expression as compared to the uninduced cells.

Mesenchymal Stem Cells: Angels or Demons?

  • R. Wong
  • Medicine, Biology
    Journal of biomedicine & biotechnology
  • 2011
The mechanism of the modulatory behaviour and the tumorigenic potential of MSCs, warrant urgent exploration, and the use of M SCs in patients with cancer awaits further evaluation.