[Study on the association between the HLA-DRB1 alleles and type 2 diabetes in Yi nationality of Yunnan].

Abstract

OBJECTIVE To investigate the association between the polymorphism of HLA-DRB1 alleles and type 2 diabetes mellitus in Yi nationality of Yunnan. METHODS Polymerase chain reaction-sequence specific primers (PCR-SSP) genotyping method was conducted in 79 patients with type 2 diabetes mellitus and 47 ethnically matched controls in Yi Nationality Autonomous Prefecture, Chuxiong. RESULTS HLA-DR7 and DR11 allele frequencies in type 2 diabetic mellitus patients were significantly higher than those in non-diabetic control subjects respectively(P is 0.009, RR is 8.329;P is 0.029, RR is 7.734). CONCLUSION DR7 and DR11 alleles are probably susceptible genes of type 2 diabetes mellitus in Yunnan Yi nationality.

Cite this paper

@article{Yang2007StudyOT, title={[Study on the association between the HLA-DRB1 alleles and type 2 diabetes in Yi nationality of Yunnan].}, author={Hong-Ying Yang and Li Xue and Mian Xu and Chun-feng Ren and Hui-yun Yuan and Wen-lin Tai and Yu Yang and Wei He}, journal={Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics}, year={2007}, volume={24 1}, pages={101-3} }