Study on the DME-cytochromeb5 and its mutants at site of F58

  title={Study on the DME-cytochromeb5 and its mutants at site of F58},
  author={H. Su and Junxia Lu and Yun-hua Wang and Yi Ren and Y. Xie and Z. Huang},
  journal={Chinese Science Bulletin},
Phenylalanine-58 is one of the conservative residues in the hydrophobic pocket of Cytb5, which forms aromatic stacking with the hemeb. Previous study showed that both the stacking and the property of the aromatic residue affect hydrophobicity of the heme pocket, leading to change of protein’s property. In order to further reveal the essence we esterify the heme propionate of Cytb5, F58Y.and F58W, and eliminate the hydrogen bond between heme propionate and Ser64 in examining the effect of… Expand
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