Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers.

@article{Hosoe2007StudyOS,
  title={Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers.},
  author={Kazunori Hosoe and Mitsuaki Kitano and Hideyuki Kishida and Hiroshi Kubo and Kenji Fujii and Mikio Kitahara},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2007},
  volume={47 1},
  pages={
          19-28
        }
}
The safety and bioavailability of ubiquinol (the reduced form of coenzyme Q(10)), a naturally occurring lipid-soluble nutrient, were evaluated for the first time in single-blind, placebo-controlled studies with healthy subjects after administration of a single oral dose of 150 or 300 mg and after oral administration of 90, 150, or 300 mg for 4 weeks. [...] Key Result No clinically relevant changes in results of standard laboratory tests, physical examination, vital signs, or ECG induced by ubiquinol were…Expand
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The safety profile of Coenzyme Q10 at high doses for healthy subjects was assessed in a double-blind, randomized, placebo-controlled study and showed that Kaneka Q10 was well-tolerated and safe for healthy adults at intake of up to 900 mg/day. Expand
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Abstract The objective of this study was to compare the relative bioavailability of two new products with solubilized and non-solubilized over-the-counter (OTC) coenzyme Q 10 products. Nine healthyExpand
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Overall, CoQ(10) was well tolerated by male and female rats at dose levels up to 1200 mg/(kg day); high incidence of orange, granular, lumenal exudate in nasal turbinates and lung findings were probably secondary to incidental exposure to crystallized test material. Expand
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The serum level of UQH2-10 correlated significantly with those of vitamin E (p less than 0.001), vitamin E, phospholipids, cholesterol, total cholesterol, lipid peroxides, and total lipids, and there was no correlationship between the serum levels of UZH1-10 and of triglycerides and lipidperoxides. Expand
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