Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers.

@article{Hosoe2007StudyOS,
  title={Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers.},
  author={Kazunori Hosoe and Mitsuaki Kitano and Hideyuki Kishida and Hiroshi Kubo and Kenji Fujii and Mikio Kitahara},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2007},
  volume={47 1},
  pages={
          19-28
        }
}

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References

SHOWING 1-10 OF 57 REFERENCES

52-Week oral gavage chronic toxicity study with ubiquinone in rats with a 4-week recovery.

Overall, CoQ(10) was well tolerated by male and female rats at dose levels up to 1200 mg/(kg day); high incidence of orange, granular, lumenal exudate in nasal turbinates and lung findings were probably secondary to incidental exposure to crystallized test material.

Subchronic Oral Toxicity of Ubiquinol in Rats and Dogs

The subchronic toxicity of ubiquinol was evaluated and compared in Sprague-Dawley rats and beagle dogs, and test article–related effects on the liver, spleen, and mesenteric lymph node in female rats but not in male rats.

Relative bioavailability of coenzyme Q10 formulations in human subjects.

  • R. ChopraR. GoldmanS. SinatraH. Bhagavan
  • Chemistry
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 1998
The data from both trials show that Q-Gel, the new solubilized form of CoQ10, is vastly superior to typical commercially available preparations of Co Q10, which means much lower doses of Q- Gel will be required to rapidly reach and maintain adequate blood CoQ 10 values than with any of the other currently available products.

Comparative bioavailability of two novel coenzyme Q10 preparations in humans.

The novel fast-melting and effervescent formulations provide a more rapid delivery of CoQ10 to the blood while exhibiting a similar AUC compared with current formulations.

Bioavailability of four oral coenzyme Q10 formulations in healthy volunteers.

Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease

A new Coenzyme Q10 tablet-grade formulation (all-Q) is bioequivalent to Q-Gel and both have better bioavailability properties than Q-SorB.

The kinetic profiles of all CoQ10 preparations revealed a one-peak plasma concentration-time course, and highest Cmax values were seen after Q-Gel application, whereas time to Cmax was nearly identical across all treatments.

Human serum ubiquinol-10 levels and relationship to serum lipids.

  • T. OkamotoT. MatsuyaY. FukunagaT. KishiT. Yamagami
  • Medicine, Biology
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 1989
The serum level of UQH2-10 correlated significantly with those of vitamin E (p less than 0.001), vitamin E, phospholipids, cholesterol, total cholesterol, lipid peroxides, and total lipids, and there was no correlationship between the serum levels of UZH1-10 and of triglycerides and lipidperoxides.
...