Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis

@article{Shirai2007StudyOR,
  title={Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis},
  author={Tomokazu Shirai and Koki Fujimura and Chikara Furusawa and Keisuke Nagahisa and Suteaki Shioya and Hiroshi Shimizu},
  journal={Microbial Cell Factories},
  year={2007},
  volume={6},
  pages={19 - 19}
}
BACKGROUND Corynebacterium glutamicum has several anaplerotic pathways (anaplerosis), which are essential for the productions of amino acids, such as lysine and glutamate. It is still not clear how flux changes in anaplerotic pathways happen when glutamate production is induced by triggers, such as biotin depletion and the addition of the detergent material, Tween 40. In this study, we quantitatively analyzed which anaplerotic pathway flux most markedly changes the glutamate overproduction… CONTINUE READING

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