Study on pharmacokinetics and nephrotoxicity of netilmicin in rabbits using a new dosage regimen.

Abstract

The potential nephrotoxicity and pharmacokinetic parameters of netilmicin were investigated in rabbits after single and multiple dosage regimens (7 mg/kg/12 h) allometrically equivalent to a once-daily regimen of 5 mg/kg/24 h in man. Netilmicin was determined in plasma and renal tissue by a high-performance liquid chromatography (HPLC) technique with… (More)

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@article{Santos1997StudyOP, title={Study on pharmacokinetics and nephrotoxicity of netilmicin in rabbits using a new dosage regimen.}, author={Marisa Santos and Miguel F. Arevalo and Clara Isabel Colino and F. G. L{\'o}pez and Arcadi Navarro and Alfonso Dom{\'i}nguez-Gil and Jos{\'e} Mart{\'i}nez Lanao}, journal={Methods and findings in experimental and clinical pharmacology}, year={1997}, volume={19 1}, pages={53-9} }