Study on intestinal absorption sites of mizoribine and ribavirin, substrates for concentrative nucleoside transporter(s), in rats.

@article{Mori2010StudyOI,
  title={Study on intestinal absorption sites of mizoribine and ribavirin, substrates for concentrative nucleoside transporter(s), in rats.},
  author={Nobuhiro Mori and Tomoharu Yokooji and Y Kamio and Teruo Murakami},
  journal={European journal of pharmacology},
  year={2010},
  volume={628 1-3},
  pages={
          214-9
        }
}
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Data indicate that ribavirin is a transported permeant for the es nucleoside transporter of human erythrocytes, a cell type that lacks the NBMPR‐sensitive (es) nucleosideside transporter, and via a pathway that was resistant to N BMPR inhibition.
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It is demonstrated that in general, tissue distribution of Cnt and Ent is similar in rats and mice, however, a few important species and gender differences do exist, which could be responsible for related differences in efficacy and toxicity of substrates for these transporters.
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The complex pattern of NT isoform expression in mammalian cells can fulfill physiological roles other than salvage, as well as under purinergic control, in a manner that is dependent on energy metabolism.
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