Study on gracillin derivatives and their antitumor activity

@inproceedings{Lih2015StudyOG,
  title={Study on gracillin derivatives and their antitumor activity},
  author={Lu Li-h},
  year={2015}
}
By the means of hydrolysis and esterification,11 gracillin derivatives were prepared. Six of them( Ⅰ,Ⅱ,Ⅴ,Ⅵ,Ⅸ,Ⅺ) were new compounds.Their structures were confirmed by1 H NMR,13 C NMR,and MS spectrum.Their in vitro antitumor activity were tested on K562 and Hep G-2 cells.Result showed that compoundsⅨ and Ⅺ had interesting activity.IC50 of compounds Ⅸ on two kinds of tumor cells were 3.66 μg / m L and 21.47μg /m L,respectively.It was also found that the quantity of sugar on compounds could affect… CONTINUE READING

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